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KMID : 1164220130250010025
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Journal of Korean Society for Radiotherapeutic Technology
2013 Volume.25 No. 1 p.25 ~ p.31
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Robust Planning of Intensity-modulated Proton Therapy for Prostate Cancer
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Park Su-Yeon
Kim Jong-Sik
Park Ju-Young
Park Won
Ju Sang-Gyu
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Abstract
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Purpose: The aim of this study is to evaluate the dosimetric properties of robust planning strategy for plain
intensity-modulated proton therapy (IMPT) taking into account of the uncertainties of effective proton range and set
up error as compared to photon intensity-modulated radiation therapy (photon-IMRT) in prostate cancer treatment.
Materials and Methods: The photon-IMRT (7 beams, step & shoot), plain-IMPT (2, 4, and 7 portals), and robust-
IMPT plans, which was recalculated the plain-IMPT based on the uncertainties of range error (±5%) and set up
error (0.5 cm), were evaluated for five prostate cancer patients prescribed by 70 Gy/35 fractions. To quantitatively
evaluate the dose distributions, several parameters such as maximum dose, minimum dose, mean dose, conformity
index (CI), and homogeneity index (HI) for PTV as well as dose-volume index of VxGy for OARs were calculated
from dose-volume histograms.
Results: Robust-IMPT showed superior dose distributios in the PTV and OARs as compared to plain-IMPT and
photon-IMRT. Like plain-IMPT, robust-IMPT were resulted in dose fluctuation around OARs, while better homogeneity
and conformity in PTVs and lower mean dose in OARs as compared to photon-IMRT.
Conclusion: In consideration with the effective range correction and set up movement using robustness in IMPT
plan, the dosimetric uncertainties from plain-IMPT could substantially reduce and suggest more effective solutions
than photon-IMRT in prostate cancer treatment.
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KEYWORD
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prostate cancer, robust-IMPT, effective proton range, set up error
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